Women have a tendency to feel exactly the identical side effects of cannabis as men using a lesser dose of THC, according to a study by Canadian researchers. Basically saying that the THC impact on women is greater than men.
Justin Matheson, a Ph.D. candidate in the University of Toronto and lead author of the research, advised psychology and neurosciences news site PsyPost that previous study has shown differences in how men and women use cannabis.
“We all know from population survey statistics that men are more likely to use cannabis than women, but it feels like women experience more intense cannabis-related injuries,”stated Matheson.
To conduct the study, which tried to replicate how people really use cannabis, 91 test subjects smoked one cannabis joint, together with 12.5percent THC or a placebo. Test subjects had their THC degrees and vital signs monitored and finished abstract influence scales and cognitive evaluations after smoking the joint. The THC impact on women versus the THC impact on men was compared.
The researchers found that women smoked for exactly the exact same period of time as men, though they have less of the joint. Regardless of the gap in consumption, however, men and women exhibited no difference in peak drugs effects, mood, and cognitive results.
“We discovered that women smoked less of a cannabis joint, had reduced rates of THC in blood, nevertheless experienced the exact same severe effects as men,” clarified Matheson. “So, I believe that the principal take-away is that women might require a lower dose of THC for to the identical amount of intoxication as men.”
Matheson noted the analysis was designed so the test areas could smoke the total amount of cannabis that they wanted.
“When participants smoke for their desirable high, we call this’titrating to influence,”’ he explained. “Titrating to impact will be possible when smoking cannabis since THC delivery into the mind is quite fast with this course of administration, so users may feel that the high since they’re smoking.”
“But with additional cannabis products such as edibles or drinks with a delayed onset of activity, it’s not feasible to titrate to influence,” Matheson continued. “In such instances, women are probably at greater risk of having severe harms.”
Matheson noted the analysis was subject to constraints, such as the differences between sex and gender when measuring the THC impact on women variations to the THC impact on men.
“The significant thing here is that we believed sex as a binary biological factor (male vs. female) and we had no real measure of sex,” he explained. “Sex is a biological construct that reflects things such as sex chromosomes, hormones, anatomy, and physiology, although sex is a social and cultural construct which reflects things such as our sex identity (male, female, or gender-diverse) along with also the expectations which our societies have for us based on these identities”
Matheson added that the analysis represents a first step into detecting sex differences from the acute effects of cannabis. Finding out the cause of these differences will need more study, which might show that both sex and gender are included.
“For instance, there’s evidence that estrogen (a sex hormone) affects the metabolism of THC, which might explain some of these sex differences in the metabolism of THC people view,” he explained. “But we also understand that gender identity affects drug use behaviours, which might relate to the reason we found that women smoked less of their cannabis joint”